If you run Web browser under the protection of Sandboxie, all malicious software downloaded by the browser is trapped in the sandbox and can be discarded trivially. So when you throw away the sandbox, all the history records and other side-effects of your browsing disappear as well.
An isolated virtual environment allows to control testing of untrusted programs and web surfing. There you can run or install all applications without permanently modifying the local or mapped drive. It creates a sandbox-like isolated operating environment. Sandboxie is a proprietary sandbox based isolation program for Windows operating systems.